Publications by authors named "G B HAMILTON"
Background And Objective: The impact of lifetime body mass index (BMI) trajectories on adult lung function abnormalities has not been investigated previously. We investigated associations of BMI trajectories from childhood to mid-adulthood with lung function deficits and COPD in mid-adulthood.
Methods: Five BMI trajectories (n = 4194) from age 5 to 43 were identified in the Tasmanian Longitudinal Health Study.
Pleomorphic rhabdomyosarcoma (PRMS) is an extremely rare soft tissue tumor with dismal prognosis that has a higher incidence in adults compared to the other RMS subtypes. The unique PRMS cell line BH1522 was established from a pleural effusion of a lung metastasis and the characteristics of this cell line were compared to two embryonal type RMS (ERMS) cell lines. The affected patient had been treated by surgery, several cycles of chemotherapy and thoracoscopy of the lung metastases.
View Article and Find Full Text PDFThe Trypanosoma brucei genome is structurally complex. Eleven megabase-sized chromosomes each comprise a transcribed core flanked by silent subtelomeres, housing thousands of Variant Surface Glycoprotein (VSG) genes. Additionally, hundreds of sub-megabase chromosomes contain 177 bp repeats of unknown function, and VSG transcription sites localise to many telomeres.
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- Researchers studied 1485 patients undergoing invasive coronary angiography (ICA) to predict the likelihood of severe multivessel disease (MVD), which can impact decisions about transradial access (TRA) in coronary artery bypass grafting (CABG).
- The predictive model showed a sensitivity of 70.3% and specificity of 71.8%, with a strong negative predictive value of 94.4%, indicating its effectiveness in identifying patients who may not have severe MVD.
- Key indicators of severe MVD included abnormal test history, typical chest pain, and diabetes, while factors indicating the absence of severe MVD included female sex, atypical chest pain, and BMI, helping clinicians tailor access strategies for CABG based on individual patient
Article Synopsis
- The study investigates night-to-night variability (NtNV) in obstructive sleep apnea (OSA) severity and looks for predictors of this variability.
- 71 OSA patients underwent two sleep studies to analyze their apnea-hypopnea index (AHI), endotypes, and airflow limitations.
- Results revealed significant variability in AHI, but no strong correlations were found between AHI variability and changes in OSA endotypes, suggesting the complexity of predicting OSA severity.