Publications by authors named "G B Corona"
Article Synopsis
- The hypothalamus-pituitary testis axis and growth hormone (GH) pathways are interconnected, but GH's impact on male sexual function and fertility remains debated due to mixed research findings.
- GH excess contributes to male sexual health issues, notably causing erectile dysfunction in about 40.2% of cases and impairing fertility by reducing sperm quality, including concentration and motility.
- GH deficiency may also lead to erectile dysfunction, though its effects on fertility are not well established; overall, GH disorders adversely affect male sexual and general health, with insufficient research on testosterone replacement therapy benefits.
Introduction: Erectile dysfunction (ED) is a neglected complication in patients with pre-diabetes or diabetes mellitus (DM).
Areas Covered: A summary and review of the role of standard ED treatment and the contribution of lifestyle modification and hypoglycemic drugs.
Expert Opinion: Oral phosphodiesterase type 5 inhibitors (PDE5i) represent the first-line therapy even in patients with DM.
Article Synopsis
- * A meta-analysis of 12 studies involving 345 obese men showed that weight loss significantly improved sperm concentration and motility, and reduced DNA fragmentation in sperm.
- * The findings suggest that weight loss could enhance sperm quality, indicating it may be beneficial for obese men experiencing fertility issues during attempts to conceive.
Background: Although nutraceutical-based treatments are often offered for erectile dysfunction (ED), their efficacy remains doubtful, and the choice of one substance over the other is challenged by the dearth of head-to-head comparative studies.
Aim: We aimed to compare the efficacy of available nutraceutical interventions, alone or in combination with phosphodiesterase type 5 inhibitors (PDE5i), in improving erectile function in men with ED through a network meta-analysis (NMA), which incorporates direct and indirect evidence into one model thus generating a hierarchy of effectiveness.
Methods: PubMed, Scopus, Web of Sciences, and Cochrane Library databases were searched for randomized placebo-controlled trials (RCTs) assessing the effect of any nutraceutical regimen in improving erectile function when compared to each other, placebo, and/or PDE5i in men with ED.
Purpose: Although anti-hypertensive medications, including thiazides and β-blockers (BBs) in particular, have been suggested to cause erectile dysfunction (ED) their real contribution is still conflicting. The aim of this paper is to summarize available evidence providing an evidence-based critical analysis of the topic.
Methods: An overall comprehensive narrative review was performed using Medline, Embase and Cochrane search.