Designing a sector-coupled European energy system robust to 60 years of historical weather data.

As energy systems transform to rely on renewable energy and electrification to mitigate climate change, they encounter stronger year-to-year variability in energy supply and demand. Yet, most infrastructure planning relies on a single weather year, risking a potential lack of robustness. In this paper, we optimize capacity layouts for a European energy system under net-zero CO emissions for 62 different weather years.

3D-printed wound dressing platform for protein administration based on alginate and zinc oxide tetrapods.

Wound treatment requires a plethora of independent properties. Hydration, anti-bacterial properties, oxygenation and patient-specific drug delivery all contribute to the best possible wound healing. Three-dimensional (3D) printing has emerged as a set of techniques to realize individually adapted wound dressings with open porous structure from biomedically optimized materials.

Using Modeling All Alternatives to explore 55% decarbonization scenarios of the European electricity sector.

Climate change mitigation is a global challenge that, however, needs to be resolved by national-level authorities, resembling a "tragedy of the commons". This paradox is reflected at the European scale, as climate commitments are made by the EU collectively, but implementation is the responsibility of individual Member States. Here, we investigate a suite of near-optimal effort-sharing scenarios where the European electricity sector is decarbonized between 55% and 75% relative to 1990, in line with 2030 ambitions.

Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis.

The metalloproteases meprin α and meprin β are highly expressed in the healthy gut but significantly decreased in inflammatory bowel disease, implicating a protective role in mucosal homeostasis. In the colon, meprin α and meprin β form covalently linked heterodimers tethering meprin α to the plasma membrane, therefore presenting dual proteolytic activity in a unique enzyme complex. To unravel its function, we applied N-terminomics and identified galectin-3 as the major intestinal substrate for meprin α/β heterodimers.