Modification of the Polymer of a Bone Cement with Biodegradable Microspheres of PLGA and Loading with Daptomycin and Vancomycin Improve the Response to Bone Tissue Infection.

Unlabelled: Chronic infections are one of the most serious adverse outcomes of prosthetic surgery. Prosthetic revision surgery using a bone cement loaded with antibiotics between the two stages of the surgery is commonly performed. However, this method often fails to reach the minimum inhibitory concentration and promotes antibiotic resistance, thus emphasizing the need for improving the current available therapies.

Damage Localization in Composite Plates Using Wavelet Transform and 2-D Convolutional Neural Networks.

Nondestructive evaluation of carbon fiber reinforced material structures has received special attention in the last decades. Usage of Ultrasonic Guided Waves (UGW), particularly Lamb waves, has become one of the most popular techniques for damage location, due to their sensitivity to defects, large range of inspection, and good propagation in several material types. However, extracting meaningful physical features from the response signals is challenging due to several factors, such as the multimodal nature of UGW, boundary conditions and the geometric shape of the structure, possible material anisotropies, and their environmental dependency.

Influence and Compensation of Temperature Effects for Damage Detection and Localization in Aerospace Composites.

Structural Health Monitoring (SHM) of Carbon Fiber Reinforced Polymers (CFRP) has become, recently, in a promising methodology for the field of Non-Destructive Inspection (NDI), specially based on Ultrasonic Guided Waves (UGW), particularly Lamb waves using Piezoelectric Transducers (PZT). However, the Environmental and Operational Conditions (EOC) perform an important role on the physical characteristics of the waves, mainly the temperature. Some of these effects are phase shifting, amplitude changes and time of flight (ToF) variations.

Polylactic-co-glycolic acid microspheres added to fixative cements and its role on bone infected architecture.

Joint prostheses are an essential element to improve quality of life. However, prostheses may fail due to several factors, including the most frequent cause, Staphylococcus aureus infection. The identification of new fixing bone cements with less reactivity on bone tissue and an adequate response to infection remains a primary challenge.

Experimental study of the application of a new bone cement loaded with broad spectrum antibiotics for the treatment of bone infection.

Objectives: To evaluate the in vivo behaviour of a new bone cement loaded with antibiotics, in a rabbit bone infection model.

Material And Methods: Sixteen New Zealand rabbits divided into 4 groups were used, depending on the cement (commercial or experimental) and the antibiotic (vancomycin or linezolid) used to control a bone infection caused by Staphylococcus aureus. The commercial cement is Palacos R and the experimental cement has been achieved by adding PLGA to the solid phase of Palacos R cement.