Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia.

The COVID-19 pandemic continues to be a health crisis with major unmet medical needs. The early responses from airway epithelial cells, the first target of the virus regulating the progression toward severe disease, are not fully understood. Primary human air-liquid interface cultures representing the broncho-alveolar epithelia were used to study the kinetics and dynamics of SARS-CoV-2 variants infection.

Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia.

The COVID-19 pandemic continues to be a health crisis with major unmet medical needs. The early responses from airway epithelial cells, the first target of the virus regulating the progression towards severe disease, are not fully understood. Primary human air-liquid interface cultures representing the broncho-alveolar epithelia were used to study the kinetics and dynamics of SARS-CoV-2 variants infection.

Possible role of beta-blockers in the prevention of sudden cardiac death (SCD) in patients with coronary heart disease (CHD).

The prevention of sudden cardiac death remains one of the greatest challenges in the field of cardiovascular medicine today. Despite the difficulty in predicting which individuals are going to die suddenly, much knowledge has accumulated in recent years in regard to independent risk factors for SCD and moreover, different pharmacological interventions have been evaluated for the prevention of sudden coronary death. Currently, the beta-blockers are the only pharmacological agents that have been shown to reduce sudden cardiac deaths in clinical trials.

[Non-prolapsing atrial myxoma. Description of a clinical and echocardiographic case].

A clinically and sonographically identified case of atrial myxoma with no prolapse due to its short peduncle is described with emphasis on the importance of 2D echocardiography given the lack of both clinical symptoms and Time Motion ultrasound data in atrial myxomas prolapsing through the mitral anulus into the ventricular cavity. In fact 2D echocardiography shows up the systolic-diastolic swing of the tumour mass between the lower third of the left atrium and the atrioventricular valvular plane.