Publications by authors named "G Alvarez-Llamas"
Background: Current definition of chronic kidney disease (CKD) identifies only advanced stages, but effective management demands early detection. Urinary albumin-to-creatinine ratio (ACR) 30 mg/g is a cut-off point for CKD clinical diagnosis. Patients with lower values (normoalbuminuria) and eGFR > 60 mL/min/1.
View Article and Find Full Text PDFBackground And Objective: Extracellular vesicles (EV) reflect the pathophysiological state of their cells of origin and are a reservoir of renal information accessible in urine. When biopsy is not an option, EV present themselves as sentinels of function and damage, providing a non-invasive approach. However, the analysis of EV in urine requires prior isolation, which slows down and hinders transition into clinical practice.
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- Early diagnosis of chronic kidney disease (CKD) is crucial, as even patients with a normal albumin-to-creatinine ratio (ACR) show increased health risks, indicating the need for better assessment tools.
- This study focuses on identifying glycoproteins linked to kidney damage in patients with high-normal ACR using mass spectrometry, revealing significant differences between these patients and those with lower ACR.
- Findings show that certain glycoproteins, particularly related to iron metabolism, could be early indicators of CKD progression, with implications for both male and female patients.
Analysis of Vascular Smooth Muscle Cells from Thoracic Aortic Aneurysms Reveals DNA Damage and Cell Cycle Arrest as Hallmarks in Bicuspid Aortic Valve Patients.
J Proteome Res
August 2024
Article Synopsis
- Thoracic aortic aneurysm (TAA) is often sporadic and more common in patients with a bicuspid aortic valve (BAV), although the reasons for this are not fully understood.
- The study examined differences in molecular characteristics between aortic dilatation in patients with BAV and those with a tricuspid aortic valve (TAV) by analyzing vascular smooth muscle cells and plasma proteins.
- Findings revealed that BAV-TAA patients experience higher oxidative stress and DNA damage, while distinct plasma markers suggest a need for tailored treatment strategies for BAV and TAV patients.
Background: The metabolic alterations occurring within the arterial architecture during atherosclerosis development remain poorly understood, let alone those particular to each arterial tunica. We aimed first to identify, in a spatially resolved manner, the specific metabolic changes in plaque, media, adventitia, and cardiac tissue between control and atherosclerotic murine aortas. Second, we assessed their translatability to human tissue and plasma for cardiovascular risk estimation.
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