Publications by authors named "G Alexander Hamilton"
Article Synopsis
- Researchers studied 1485 patients undergoing invasive coronary angiography (ICA) to predict the likelihood of severe multivessel disease (MVD), which can impact decisions about transradial access (TRA) in coronary artery bypass grafting (CABG).
- The predictive model showed a sensitivity of 70.3% and specificity of 71.8%, with a strong negative predictive value of 94.4%, indicating its effectiveness in identifying patients who may not have severe MVD.
- Key indicators of severe MVD included abnormal test history, typical chest pain, and diabetes, while factors indicating the absence of severe MVD included female sex, atypical chest pain, and BMI, helping clinicians tailor access strategies for CABG based on individual patient
Article Synopsis
- The study investigates night-to-night variability (NtNV) in obstructive sleep apnea (OSA) severity and looks for predictors of this variability.
- 71 OSA patients underwent two sleep studies to analyze their apnea-hypopnea index (AHI), endotypes, and airflow limitations.
- Results revealed significant variability in AHI, but no strong correlations were found between AHI variability and changes in OSA endotypes, suggesting the complexity of predicting OSA severity.
Background: Approximately 30% of the non-small cell lung cancer (NSCLC) patients which harbor no recognizable oncogenic driver mutation are not eligible for targeted therapy. Functional drug screening of tumor cells helps to identify susceptible drug targets not recognized by gene panels for targeted mutation analysis. The aim of this study is to characterize the BH1406 cell line carrying an activating SOS1 mutation and to check its sensitivity to cognate inhibitors.
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- Fat grafting is widely used in aesthetic and reconstructive surgery but can experience complications like fat necrosis, which is influenced by factors such as fat aspiration and graft size.
- The study explored how the expression of vascular endothelial growth factor A (VEGF) and various cytokines by adipose-derived stromal cells (ADSCs) and differentiated adipocytes affects fat graft survival and angiogenesis.
- Results showed that many ADSCs have high VEGF levels, promoting tissue survival post-transfer, but differentiation into adipocytes can take time and may not provide immediate support for angiogenesis.
Background: Life-course lung function trajectories leading to airflow obstruction, as measured by impaired FEV/FVC (forced vital capacity), precede the onset of chronic obstructive pulmonary disease (COPD). We aimed to investigate whether individuals on impaired FEV/FVC trajectories have an increased burden of respiratory symptoms, including those who do not meet the spirometric criteria for COPD.
Methods: We analysed serial life-course data from two population-based cohort studies separately, which included respiratory symptoms and spirometry: the Tasmanian Longitudinal Health Study (TAHS, Australia) cohort was recruited at age 6-7 years and followed up until middle age (mean age 53 years; range 51-55); and the Coronary Artery Risk Development in Young Adults (CARDIA, USA) cohort was recruited at a mean age of 25 years (range 18-30) and followed up to a mean age of 55 years (range 47-64).