"De novo" carcinoma or early rectal carcinoma incidence and diagnostic.

The authors studied the development of "de novo" carcinomas, i.e. carcinomas which develop directly in the mucosa without having passed via an adenomatous phase.

[Primperan and gastroesophageal reflux. Review of the literature].

After reviewing its mechanism of action, the author summarises the action of Primperan in gastro-oesophageal reflux. Various studies have shown that the intravenous or oral administration of a single dose of Primperan induces an increase in the tone of the inferior oesophageal sphincter and an acceleration of gastric emptying in patients with gastro-oesophageal reflux. A dose of at least 10 mg is required.