Characterisation, management, and outcomes of New Delhi metallo-β-lactamase-producing Escherichia coli: A case series.

Objective: New Delhi metallo-β-lactamase (NDM)-producing carbapenem-resistant Enterobacterales (CRE) is a globally growing threat. We sought to describe the microbiology, management and outcomes of patients with this infection at our facility.

Methods: This is a descriptive case series of patients with NDM-producing Escherichia coli isolated from culture in Detroit between July 2021 and February 2023.

Use of whole genomic sequencing to detect New Delhi metallo-B-lactamase (NDM)-producing outbreak associated with endoscopic procedures.

Background: Whole-genome sequencing (WGS) has emerged as an alternative genotyping tool for outbreak investigations in the healthcare setting. We describe the investigation and control of a New Delhi metallo-B-lactamase (NDM)-producing cluster in Southeast Michigan.

Methods: Michigan Bureau of Laboratories identified several closely related NDM-producing isolates with WGS.

Outcomes associated with SARS-CoV-2 reinfection in individuals with natural and hybrid immunity.

Background: Studies comparing SARS-CoV-2 reinfection outcomes among individuals with previous infection (natural immunity) and previous infection plus vaccination (hybrid immunity) are limited.

Methods: Retrospective cohort study comparing SARS-CoV-2 reinfection among patients with hybrid immunity (cases) and natural immunity (controls) from March 2020 to February 2022. Reinfection was defined as positive PCR> 90 days after initial laboratory-confirmed SARS-CoV-2 infection.

Vaccine coverage and factors associated with vaccine adherence in persons with HIV at an urban infectious disease clinic.

Information on vaccination rates and factors associated with adherence in persons with HIV (PWH) is limited. We report vaccine adherence in 653 adult PWH attending an urban Infectious Disease Clinic from January 2015 to December 2021. Vaccines evaluated included influenza, pneumococcal, tetanus, hepatitis A virus (HAV) and hepatitis B virus (HBV), human papillomavirus (HPV), and zoster vaccines.

Role of diagnostic stewardship in reducing healthcare-facility-onset infections.

We describe the implementation of an electronic medical record "hard stop" to decrease inappropriate testing across a 5-hospital health system, effectively reducing the rates of healthcare-facility-onset infection. This novel approach included expert consultation with medical director of infection prevention and control for test-order override.