Publications by authors named "G Ahangari"
Background And Objective: Globally, Gastric Cancer (GC) ranks as the fifth leading cause of cancer-related deaths. GC is a multifaceted malignancy with diverse etiologies; however, understanding the shared molecular mechanisms can aid in discovering novel targeted therapies for GC. This study has employed a drug repositioning approach to explore new drug candidates for treating GC.
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- - The study explores the combined treatment of Cabergoline and Mdivi-1 to counteract the changes caused by prolonged morphine exposure on neural cells, focusing on their effectiveness against neuroadaptive responses in human neuroblastoma and glioblastoma cell lines.
- - Findings suggest that this combination therapy can normalize autophagy, reduce oxidative stress, mitigate cell death, and restore important protein expressions, providing insights into morphine's impact on mitochondrial dynamics and the dopaminergic pathway.
- - The research identifies potential neuroprotective markers (BDNF and PCNA) for assessing drug effectiveness against opioid toxicity and highlights the need for more studies to explore new treatment avenues in the context of addiction and neural cell adaptability.
Background: Gastric cancer (GC) is the fifth most common cancer worldwide and the most commonly diagnosed cancer in Iran. The nervous system provides proximity to tumor cells by releasing neurotransmitters such as dopamine and presenting them to the corresponding receptor-bearing tumors. While nerve fibers infiltrate the tumor microenvironment, little is known about the expression levels of dopamine (DA), dopamine receptors (DRs), and catechol-O-methyltransferase (COMT) in GC patients.
View Article and Find Full Text PDFIntroduction: Gastric cancer is one of the common causes of cancer-related death in the world. Neurotransmitters have recently been related to the proliferation of cancer cells, but the role of neurotransmitters in the progression of gastric cancer is still unexplored. The cross-talk between the nervous system and immune cells through serotonin and its receptors in the tumor microenvironment can impact tumor progress.
View Article and Find Full Text PDFThe Dopamine Gene Receptors (DRD) Expression Alteration in Psoriasis Patients.
Recent Adv Inflamm Allergy Drug Discov
January 2023
Background: Psoriasis is a chronic inflammatory autoimmune disease that is considered linked to genetic and environmental factors such as stress. Since the neurotransmitter dopamine has a close association with stress configuration, it can be a candidate for relieving psoriasis representation. In addition to the CNS, immune cells can play a decisive role in regulating immune functions through dopamine synthesis and the expression of its receptors.
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