Safety, reactogenicity, and immunogenicity of Ad26.COV2.S co-administered with a quadrivalent standard-dose or high-dose seasonal influenza vaccine: a non-inferiority randomised controlled trial.

Background: Vaccine co-administration can increase vaccination coverage. We assessed the safety, reactogenicity, and immunogenicity of concomitant administration of Ad26.COV2.

Ethnic-racial discrimination, identity, and out-group contact in context: A systematic review of daily process studies.

Objectives: Understanding how ethnicity and race shape individuals' everyday experiences in context is critical for advancing scientific rigor and addressing ethnic-racial inequities. Daily process studies (e.g.

Estimating the contribution of early and late noise in vision from psychophysical data.

Human performance in psychophysical detection and discrimination tasks is limited by inner noise. It is unclear to what extent this inner noise arises from early noise (e.g.

Contribution of Video Directly Observed Therapy (VDOT) to Tuberculosis Treatment in Brazil.

Directly Observed Treatment (DOT) involves the administration of medication and in-person monitoring by a healthcare team alongside the patient to improve adherence to tuberculosis (TB) treatment. Implementing DOT requires healthcare professionals, transportation, time dedication, and presence at the patient's residence. Meeting all these conditions is not always possible to address the high demand of TB patients who would benefit from this supervision.

Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron.

Throughout the animal kingdom, several members of the basic helix-loop-helix (bHLH) family act as proneural genes during early steps of nervous system development. Roles of bHLH genes in specifying terminal differentiation of postmitotic neurons have been less extensively studied. We analyze here the function of 5 Caenorhabditis elegans bHLH genes, falling into 3 phylogenetically conserved subfamilies, which are continuously expressed in a very small number of postmitotic neurons in the central nervous system.