Publications by authors named "G Addolorato"

Alcohol-related liver disease (ALD) is a major cause of global morbidity and mortality, progressing from steatosis to cirrhosis and hepatocellular carcinoma. While liver biopsy remains the gold standard for identifying liver disease, non-invasive methods like shear wave dispersion (SWD) elastography offer promising alternatives. This scoping review evaluates SWD's potential in the study of ALD, comparing it to metabolic dysfunction-associated steatotic liver disease (MASLD).

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Background: Few studies have evaluated the frequency of and the reasons behind the refusal of listing liver transplantation candidates.

Aim: To assess the ineligibility rate for liver transplantation and its motivations.

Methods: A single-center retrospective study was conducted on adult patients which entailed a formal multidisciplinary assessment for liver transplantation eligibility.

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Article Synopsis
  • Alcohol use disorder (AUD) affects over 95 million people globally, has a significant hereditary component (50-60%), and can potentially be treated with low-dose ondansetron (AD04) targeting specific genetic and behavioral profiles.
  • A phase III clinical trial was conducted with 303 individuals diagnosed with AUD, focusing on those with specific genetic variants and varying levels of drinking severity.
  • Results showed that AD04 significantly reduced heavy drinking days by 46.7% compared to a 38.1% reduction in the placebo group, indicating its effectiveness in treating AUD in targeted populations.
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Article Synopsis
  • - Fever of unknown origin (FUO) can often be caused by infections, such as loxoscelism from fiddleback spider bites, which can lead to severe systemic symptoms like fever and necrotic skin lesions.
  • - A case study of a 71-year-old man highlighted the challenges in diagnosing FUO as he presented with fever, joint pain, and a necrotic arm lesion but initial tests were inconclusive; he eventually developed macrophage activation syndrome (MAS) and was diagnosed with both loxoscelism and primary cutaneous anaplastic large cell lymphoma.
  • - It's crucial to biopsy skin lesions and lymph nodes of unknown origin, as repeated evaluations may be necessary to avoid misdiagnosis, especially
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