Characterization and Validation of a Canine Pruritic Model.

Preclinical Research The mechanisms mediating canine pruritus are poorly understood with few models due to limited methods for inducing pruritus in dogs. Chloroquine (CQ) is a widely used antimalarial drug that causes pruritus in humans and mice. We have developed a canine model of pruritus where CQ reliably induced pruritus in all dogs tested following intravenous administration.

Sources of dissolved mine drainage and atmospheric transported lead: a comparative case study in Japan and Sweden.

A comparative case study in Naganobori Japan and Falun Sweden of runoff water from copper mines shows that the water and its particulates, filtered with a cutoff of 0.45 microm, have different lead isotope ratios pointing to different origins for the lead. While the larger particles have a lead ratio indicative of the atmospheric anthropogenic pollution the soluble lead has that of the copper ores.

Perceived hunger, palatability, and adherence: A comparison of high- and low-fat diets.

Objective: To investigate whether there is a difference in palatability and perceived hunger between high- and low-fat diets, and furthermore to see if any such differences are correlated with the degree of adherence to a diet and with weight reduction.

Design: Randomised, parallel, two-arm, open-label 10-week dietary intervention study comparing two hypocaloric (-600 kcal/day) diets with a fat energy percent of 20-25 or 40-45.

Subjects: Obese (BMI ≥30 kg/m(2)) but otherwise healthy adult subjects (n = 100).

Atmospheric deposition of lead in Norway: spatial and temporal variation in isotopic composition.

Moss samples collected from 22 sites all over Norway at five different times during 1977-2000 were analysed for stable lead isotope ratios. These data together with total lead concentrations and relevant literature lead isotope data from UK, western/central Europe and eastern Europe/Russia were used to elucidate major source regions for lead deposited in different parts of the country at different times. The southernmost part of the country was most affected from western/central Europe around 1975, but the deposition declined rapidly and UK became a more significant source region in the 1980s.