Publications by authors named "G AbdElHamid"
Mitochondrial DNA Alterations in Glioblastoma and Current Therapeutic Targets.
Front Biosci (Landmark Ed)
October 2024
Article Synopsis
- - Metabolic changes in tumor cells shift towards glycolysis or mitochondrial respiration depending on tumor progression, with mitochondrial dysfunction driving these changes and influencing tumor growth.
- - Mutations in mitochondrial DNA (mtDNA) have been found in tumors like glioblastoma, but many studies focus on limited parts of mtDNA, potentially missing significant mutations that affect tumor behavior.
- - Mitochondrial dysfunction impacts energy production and various signaling pathways in tumor cells, marking them as potential targets for new therapies to combat chemoresistance in glioblastoma.
This work investigates the efficiency of cholecalciferol and low dose gamma radiation in modulating cytokine storm through their impact on inflammatory and anti-inflammatory cytokine and protecting against lung and liver injuries. Male Swiss albino mice were exposed to 0.2 Gy gamma radiation/week for four consecutive weeks then injected intraperitoneally (i.
View Article and Find Full Text PDFHepatocellular carcinoma (HCC) is one of the most prevalent cancers in the world. Two risk factors that cause 80-90% of HCC cases globally are chronic infection with hepatitis B virus (HBV) and hepatitis C virus (HCV). The diagnostic value of circulating microRNAs (miRNAs) in numerous tumors has been described.
View Article and Find Full Text PDFThe process of extracting metals from rock phosphate ore (RPO) by using microorganisms to convert them into soluble compounds is called biomining. Phosphorus is one of the elements proposed to be extracted from RPO. To understand the role of Streptomyces phospholyticus, 12 isolates of Streptomyces were isolated from RPO, their ability to grow on specific phosphate solubilization medium e.
View Article and Find Full Text PDFArticle Synopsis
- * An experiment using hyperglycemic and normoglycemic mice showed that GFAP expression differed significantly; normoglycemic mice had higher GFAP levels suggesting limited infection, while hyperglycemic mice had reduced GFAP levels, indicating a failure to control the infection.
- * The study highlights the critical need for quick diagnosis of cerebral toxoplasmosis in diabetic patients and suggests using GFAP as a potential marker to track disease progression in these high-risk individuals.