Phase II randomized study of the IGF-1R pathway modulator AXL1717 compared to docetaxel in patients with previously treated, locally advanced or metastatic non-small cell lung cancer.

Background: The primary objective of this study was to compare the progression-free survival (PFS) at 12 weeks between patients treated with IGF-1R pathway modulator AXL1717 (AXL) and patients treated with docetaxel (DCT).

Material And Methods: The study was conducted at 19 study centers in five countries. A total of 99 patients with previously treated, locally advanced or metastatic non-small cell lung cancer (NSCLC) of the squamous cell carcinoma (SCC) or adenocarcinoma (AC) subtypes in need of additional treatment were randomized and treated with either 300 or 400 mg of AXL as daily BID treatment (58 patients) or DCT given as 75 mg/m in three-week cycles (41 patients) as monotherapy in a 3:2 ratio for each NSCLC subtype.

[Clinical effectiveness and safety of paroxetine in post-stroke depression: results from a phase 4, open label, multicenter clinical trial with 26 weeks of follow-up].

Introduction: Prevalence of post-stroke depression ranges from 20% to 50%. Treatment of depression positively correlated with the success of rehabilitation, quality of life, and the post-stroke patient's independence.

Aim: The primary goal of the study was to establish the therapeutic efficacy of paroxetine (measured by the changes of Hamilton Depression Scale Score) in post-stroke depression.

Temperature dependence of high accuracy photometer heads.

This Letter reports an investigation of the temperature characteristicfso r three types of high quality siliconp hotodiode and their photometric matching filters.

[The role of proximal osteomy of the tibia in the treatment of arthrosis of the knee joint].

The results of heigh tibia osteotomy performed between 1970 and 1975 in 20 cases in the material of the Orthopaedic Department of the "Semmelweis" University Medical School, Budapest, are reported. In 13 cases good--in 6 cases satisfactory results have been obtained. In 1 case the surgical intervention was of no effect.

[Comparative evaluation of results of intertrochanteric femur osteotomy and conservative hip joint releaving treatment in Perthes-Legg-Calvé disease].

In this paper the comparative evaluation of the results of the surgical and conservative treatment applied in patients with Perthes-Legg-Calvé disease is given. The results obtained with intertrochanteric femur osteotomy performed in 39 patients and those obtained in 66 patients with conservative treatment are reported. The results are evaluated from the point of view of the patients' age, the localization of the process and the stages of the disease.