Publications by authors named "G A van den Bos"

Standard citation-based bibliometric tools have severe limitations when they are applied to periods in the history of science and the humanities before the advent of now-current citation practices. This paper presents an alternative method involving the extracting and analysis of to map and analyze links between scholars and texts in periods that fall outside the scope of citation-based studies. Focusing on one specific discipline in one particular period and language area-Anglophone philosophy between 1890 and 1979-we describe a procedure to create a by identifying, extracting, and disambiguating mentions in academic publications.

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Article Synopsis
  • * Targeting inhibitory receptors like KIRs and NKG2A may enhance NK cell function, allowing for better anti-tumor responses, especially in solid tumors where current therapies struggle.
  • * The review discusses various strategies for modifying these inhibitory pathways while balancing effective activation of NK cells with safety considerations for patients.
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Article Synopsis
  • The HOVON 104 study involved 50 patients receiving bortezomib-dexamethasone therapy followed by autologous stem cell transplantation (ASCT), with 35 patients undergoing the transplantation.
  • The study reported a 5-year overall survival rate of 73% and progression-free survival of 52% for all patients, while those who received ASCT had even better outcomes, with 5-year overall survival at 91% and progression-free survival at 68%.
  • Notably, the study indicated a 60% complete response in organ function after ASCT, with cardiac responses stabilizing after 2 years and renal responses gradually improving, achieving completeness in 61% of affected patients by 5 years.
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Natural killer (NK) cells eliminate infected or cancer cells via their cytotoxic capacity. NKG2A is an inhibitory receptor on NK cells and cancer cells often overexpress its ligand HLA-E to evade NK cell surveillance. Given the successes of immune checkpoint blockade in cancer therapy, NKG2A is an interesting novel target.

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