Publications by authors named "G A el-Sayed"

Letrozole (LTZ) is an established first hormonal treatment for breast cancer, yet it was found to be highly susceptible for degradation in alkaline medium due to the presence of cyano phenyl group. Consequently, three stability-indicating spectrophotometric manipulations for LTZ quantification in presence of its alkali-induced degradation products were developed for the first time; ensuring methods' simplicity, sensitivity and accuracy. The first method was Second derivative (D) by recording peak amplitude of the drug at 226.

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Background: Nonalcoholic fatty liver disease (NAFLD) is the extremely usual reason of chronic liver disease, extending from simple hepatic steatosis (HS), nonalcoholic steatohepatitis (NASH) to advanced hepatic fibrosis and cirrhosis. Though orlistat is a Food and Drug Administration (FDA) approved drug for long-duration management of obesity, few cases of severe hepatic insult were declared. Melatonin is an efficient antioxidant; it also regulates metabolic processes that lead to fat accumulation and obesity.

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Utilizing naringenin as a safe, natural compound for reducing graphene oxide and to determine whether Nar-RGO more effectively mitigates the harmful effects of HFFD-induced NAFLD compared to crude naringenin. Using a straightforward experimental setup, we utilize the bioactive flavonoid naringenin (NAR) as the reducing agent to synthesize naringenin-reduced graphene oxide nanosheets (Nar-RGO). Naringenin loading on graphene oxide was validated using electroscopic methods (SEM and TEM) and zeta potential measurements.

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Article Synopsis
  • Researchers isolated a cellulase-producing bacterium, Bacillus amyloliquefaciens strain elh, from rice peel and used optimization methods like one-variable-at-a-time (OVAT) and response surface methodology (RSM) to increase cellulase production.* -
  • Initial cellulase activity was 0.141 U/ml, but after optimization, the peak activity reached 14.04 U/ml, and the optimal fermentation time was identified as 72 hours using specific nitrogen and sugar sources.* -
  • The cellulase-encoding gene (egl) was successfully cloned and expressed in E. coli, resulting in an activity of 22.3 U/ml, and in silico analysis showed key interactions between cellulase and
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A significant amount of dye runoff and aqueous waste are released from the manufacturing process of dyes with intense and permanent colors, which are undesirable from a cultural and ecological aspect. In this paper, we present a green, simple, low-effort, and energy-efficient method of creating magnetized cubic Zn-MOFs for the adsorption and elimination of various organic dyes. Magnetic iron oxide materials with a hierarchical structure were loaded and doped into cubic zinc metal-organic frameworks (MDLZ).

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