Publications by authors named "G A Worrell"
AN ONLINE SPIKE DETECTION AND MONITORING FRAMEWORK IN IEEG RECORDED USING BRAIN INTERCHANGE DEVICE.
Proc Int Brain Comput Interface Conf
September 2024
In this study, we developed and validated an online analysis framework in MATLAB Simulink for recording and analysis of intracranial electroencephalography (iEEG). This framework aims to detect interictal spikes in patients with epilepsy as the data is being recorded. An online spike detection was performed over 10-minute interictal iEEG data recorded with Brain Interchange CorTec in three human subjects.
View Article and Find Full Text PDFObjective: Cognitive deficits are one of the most debilitating comorbidities in epilepsy and other neurodegenerative, neuropsychiatric, and neurodevelopmental brain disorders. Current diagnostic and therapeutic options are limited and lack objective measures of the underlying neural activities. In this study, electrophysiological biomarkers that reflect cognitive functions in clinically validated batteries were determined to aid diagnosis and treatment in specific brain regions.
View Article and Find Full Text PDFThe lack of reliable seizure detection remains a significant challenge for epilepsy care. A clinical deep brain stimulation (DBS) system provides constrained ambulatory brain recordings; however, limited data exist on the use of DBS recordings for seizure detection and lateralization. We present the case of an 18-year-old patient with drug-resistant focal epilepsy, who had seizure detection and lateralization by DBS recordings.
View Article and Find Full Text PDFA Synchronous iEEG Data Acquisition Framework for Dual Brain Interchange Systems.
Conf Proc (Midwest Symp Circuits Syst)
August 2024
This study presents a new data acquisition Framework for synchronous dual Brain Interchange (BIC) systems recording. The setup expands the capacity for data recording by offering access to up to 64 channels. The environment utilizes our Simulink model, incorporating functionalities for synchronization using a master clock and email-based status updates.
View Article and Find Full Text PDFEffects of electric fields on the release and content of extracellular vesicles.
J Extracell Biol
November 2024
Article Synopsis
- Extracellular vesicles (EVs) are tiny structures released by cells that can affect other cells' behaviors and are being studied for use as biomarkers and treatment delivery in various diseases.
- The researchers hypothesized that electric fields could impact the release and content of EVs, leading to the development of a bioreactor that simulates natural cell environments while applying these electric fields.
- Their findings indicate that electrical stimulation affects EV release and contents based on frequency, suggesting possible new methods for understanding EV behavior and using electrical stimulation in treating brain disorders.