Publications by authors named "G A Wittert"
Psychological interventions for depression in people with diabetes mellitus.
Cochrane Database Syst Rev
January 2025
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To determine the effects of psychological interventions for depression in people with diabetes mellitus.
View Article and Find Full Text PDFObjective: We have shown that men aged 50 years+ at high risk of type 2 diabetes treated with testosterone together with a lifestyle program reduced the risk of type 2 diabetes at 2 years by 40% compared to a lifestyle program alone. To develop a personalized approach to treatment, we aimed to explore a prognostic model for incident type 2 diabetes at 2 years and investigate biomarkers predictive of the testosterone effect.
Design: Model development in 783 men with impaired glucose tolerance but not type 2 diabetes from Testosterone for Prevention of Type 2 Diabetes; a multicenter, 2-year trial of Testosterone vs placebo.
Objective: Sociodemographic, lifestyle, and medical variables influence total testosterone (T) and sex hormone-binding globulin (SHBG) concentrations. The relationship between these factors and "free" T remains unclear. We examined 21 sociodemographic, lifestyle, and medical predictors influencing calculated free T (cFT) in community-dwelling men across ages.
View Article and Find Full Text PDFAims/hypothesis: Night-shift work causes circadian misalignment and impairs glucose metabolism. We hypothesise that food intake during night shifts may contribute to this phenomenon.
Methods: This open-label, multi-arm, single-site, parallel-group controlled trial involved a 6 day stay at the University of South Australia's sleep laboratory (Adelaide, SA, Australia).
Article Synopsis
- The study investigates the link between obstructive sleep apnea (OSA) and the development of type 2 diabetes mellitus (T2DM) over an 8.3-year period among men who were initially free of diabetes.
- Out of 824 participants from the MAILES study, 52 (9.7%) were diagnosed with T2DM, and initial associations between OSA metrics and T2DM weakened after adjusting for factors like baseline glucose and testosterone levels.
- Key findings include that individuals with lower mean oxygen saturation levels had a significantly higher risk of developing T2DM, while other metrics of sleep apnea showed no independent association once adjustments were made.