[The Military Medical Academy's website].

The article deals with the organization of work, evaluation and optimization of the official web site of the Kirov Military Medical Academy. The website of the Kirov Academy is presented as a multifunctional IT tool for support of its activity. Tasks and functions of the Kirov Academy web site, as well as technological features of its work are listed.

[Cybernetics and biology].

Owing to methodical disadvantages, the theory of control still lacks the potential for the analysis of biological systems. To get the full benefit of the method in addition to the algorithmic model of control (as of today the only used model in the theory of control) a parametric model of control is offered to employ. The reasoning for it is explained.

[Possibilities of ultrasound diagnosis of esophageal cancer].

The investigation was undertaken to estimate the possibilities of the current ultrasound study (USS) in patients with esophageal cancer for its specifying diagnosis and the evaluation of the efficiency of performed treatment. The paper gives data on the current possibilities of ultrasound diagnosis in patients with esophageal cancer, which, during one study, makes it possible to visualize the tumor, to characterize its sizes and structure, to reveal enlarged regional lymph nodes, and to evaluate the oropharynx and abdominal organs. A definite USS program was used to examine 54 patients with verified esophageal cancer (42 (77.

Multi-terawatt picoseconds 10-μm СО2 laser system: design and parameters' control.

The basic principles for design of an advanced multi-terawatt СО(2) laser system are considered. The key amplifiers' parameters were evaluated by numerical modeling. The potential advantage of using pulsed chemical DF-СО(2) laser as a final amplifier over an electro-ionization TE-СО(2) laser is outlined.

Cyclophosphamide metabolite inducing apoptosis in RLS mouse lymphosarcoma cells is a substrate for P-glycoprotein.

RLS lymphosarcoma characterized by enhanced expression of mdr1a and mdr1b genes encoding P-glycoprotein is insensitive to low doses of cyclophosphamide, but is susceptible to its high doses approximating the maximum tolerated doses. Induction of apoptotic death of RLS cells by high doses of cyclophosphamide was demonstrated by cytofluorometry and electrophoresis. Experiments on RLS(40) tumor cells derived from RLS lymphosarcoma and characterized by more intensive expression of mdr1a/1b genes showed that the therapeutic effects of cyclophosphamide increased under conditions of simultaneous suppression of these genes by specific small interfering RNA (siRNA).