Do pain management websites foster self-management support for people with persistent pain? A scoping review.

Objectives: To evaluate if the contents of pain management websites include the current best practice self-management support strategies for people with persistent pain, are cultural tailored and to determine the website quality.

Methods: Websites were searched from three major search engines (Google, Bing, and Yahoo). Websites providing information on self-management strategies and websites that were freely available to the public were included.

Complex regional pain syndrome.

Practice development enables the practitioner to develop their knowledge and allow the application of evidence based care for patients. It happens within the practitioner's own clinical practice area and enhances personal and professional growth whilst focusing on patients' specific needs. This is important with a condition such as Complex Regional Pain Syndrome (CRPS), with patients seekingaccurate and timely diagnosis and coping strategies to support them in everyday activities.

Distribution of omega-Conotoxin GVIA binding sites in teleost cerebellar and electrosensory neurons.

The distribution of omega-Conotoxin GVIA (CgTx) binding sites was used to localize putative N-type Ca2+ channels in an electrosensory cerebellar lobule, the eminentia granularis pars posterior, and in the electrosensory lateral line lobe of a gymnotiform teleost (Apteronotus leptorhynchus). The binding sites for CgTx revealed by an anti-CgTx antibody had a consistent distribution on somatic and dendritic membranes of specific cell types in both structures. The distribution of CgTx binding was unaffected by co-incubation with nifedipine or AgaToxin IVA, blocking agents for L- and P-type Ca2+ channels, respectively.

Nitric oxide synthase in tiger salamander retina.

Previous studies have indicated that nitric oxide, a labile freely diffusible biological messenger synthesized by nitric oxide synthase, may modulate light transduction and signal transmission in the retina. In the present work, the large size of retinal cells in tiger salamander (Ambystoma tigrinum) allowed the utilization of nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase histochemistry and nitric oxide synthase immunocytochemistry to delineate the cell-specific intracellular localization of nitric oxide synthase. NADPH-diaphorase activity was highly concentrated in the outer retina, in rod and cone inner segment ellipsoids, and between and adjacent to the photoreceptor cell bodies in the outer nuclear layer.

ON and OFF activity gradients in the lateral geniculate nucleus of the cat: a combined 14C 2-deoxyglucose and D,L-2-amino-4-phosphonobutyric acid study.

Experiments on the lateral geniculate nucleus (LGN) of the cat based on 14C 2-deoxyglucose (2-DG) autoradiography and intraocular injections of 2-amino-4-phosphonobutyric acid (APB) provided evidence for gradients of metabolic activity in the ON and OFF pathways in layer A, but only very weakly, if at all, in layer A1. Alert and freely moving cats were exposed to square-wave gratings over a 45-min period after injection of the 2-DG. When one eye had been treated previously with APB, contralateral layer A showed a clear gradient of 2-DG label indicating that the remaining OFF pathway was most active ventrally in the layer and, by implication, that the ON pathway is normally most active dorsally.