Publications by authors named "G A Thomson"
Article Synopsis
- The DPB1 locus shows allele frequencies influenced by genetic drift, but specific amino acids at this locus are shaped by balancing selection, suggesting a complex relationship between drift and selection in genetic diversity.
- Using Ewens-Watterson and asymmetric Linkage Disequilibrium analyses across 136 global populations, researchers found strong evidence of balancing selection affecting DP serologic categories (SCs), while no similar selection was observed for T-cell epitopes or supertypes.
- The distribution of different SCs varies globally, with specific SCs prevalent in distinct regions, and the study highlights consistent associations between DPA1 and DP SC haplotypes, indicating that natural selection is primarily acting to preserve diversity in DP SCs rather than DPB1 alle
Introduction: Social media influencers (SMIs) are popular sources of online information on various topics, including many aspects of health. Recently, there has been an upsurge in SMIs creating content about pregnancy and parenting, including from midwives, pregnant women and parents. Despite its popularity, SMI content on pregnancy and parenting is not currently regulated, which allows for misinformation and potential harm to women and their children.
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- - Although most HLA loci show signs of balancing selection at the allele level, the DPB1 locus appears to follow neutral evolution or directional selection in many populations, despite evidence of balancing selection at the nucleotide and amino acid levels.
- - The study introduces methods to analyze the global distribution of DPB1 alleles and their amino acid sequences, allowing for a detailed investigation of natural selection's role in DPB1 diversity.
- - Findings reveal significant evidence of balancing selection at specific amino acid positions (56, 85-87, 36, 55, and 84), but not at the allele level for DPB1.
Article Synopsis
- The study aims to explore the experiences of newly qualified midwives working in a free-standing birth centre while supporting women in early labor, where professional care is often lacking in hospital settings.
- Conducted using a Heideggerian hermeneutic phenomenology approach, it involved unstructured interviews with 15 midwives over a three-year period, focusing on how they navigate care challenges during early labor.
- Analysis revealed themes related to personalizing care, intuitive knowledge, and dealing with difficult situations, highlighting the importance of building trust and enhancing relational care between midwives and women during this critical phase.
CRISPR/Cas9-mediated gene editing requires high efficiency to be routinely implemented, especially in species which are laborious and slow to transform. This requirement intensifies further when targeting multiple genes simultaneously, which is required for genetic screening or more complex genome engineering. Species in the Citrus genus fall into this category.
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