Publications by authors named "G A Swanson"
Background And Aims: Inflammatory bowel disease (IBD) flares can lead to excessive morbidity and mortality. This study aimed to determine whether oral dysbiosis/periodontal disease (PD) is common in IBD and is associated with disease activity in IBD.
Methods: This single-center, prospective, cross-sectional, proof-of-concept, observational study assessed the frequency of periodontal inflammatory disease and interrogated oral and stool microbiota using 16S rRNA gene amplicon sequencing of active-IBD (aIBD), inactive-IBD (iIBD), and healthy controls (HC).
Article Synopsis
- A multi-laboratory validation study was conducted to assess the AOAC OMA 2016.09 method, involving eight labs worldwide that tested six different raw materials and formulated products, all meeting acceptance criteria.
- The study focused on evaluating specificity, precision, linearity/range, system suitability, limit of detection (LOD), and limit of quantitation (LOQ), as accuracy and ruggedness had already been validated previously.
- Results indicated no major interferences in chromatograms for aloin A, aloin B, and aloe-emodin, with high precision (≤ 0.05 ppm differences) and strong linearity (R ≥ 0.999 across standards), confirming the method's reliability.
Introduction: Embryo implantation is a tightly regulated process, critical for a successful pregnancy. After attachment of the blastocyst to the surface epithelium of the endometrium trophoblast migrate from the trophectoderm and invade into the stromal component of endometrium. Alterations on either process will lead to implantation failure or miscarriage.
View Article and Find Full Text PDFJCO NRG Oncology RTOG 0415 is a randomized phase III noninferiority (NI) clinical trial comparing conventional fractionation (73.8 Gy in 41 fractions) radiotherapy (C-RT) with hypofractionation (H-RT; 70 Gy in 28) in patients with low-risk prostate cancer. The study included 1,092 protocol-eligible patients initially reported in 2016 with a median follow-up of 5.
View Article and Find Full Text PDFCurrent approaches to diagnosing male infertility inadequately assess the complexity of the male gamete. Beyond the paternal haploid genome, spermatozoa also deliver coding and non-coding RNAs to the oocyte. While sperm-borne RNAs have demonstrated potential involvement in embryo development, the underlying mechanisms remain unclear.
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