Publications by authors named "G A Stephenson"
Economics and Equity of Large Language Models: Health Care Perspective.
J Med Internet Res
November 2024
Large language models (LLMs) continue to exhibit noteworthy capabilities across a spectrum of areas, including emerging proficiencies across the health care continuum. Successful LLM implementation and adoption depend on digital readiness, modern infrastructure, a trained workforce, privacy, and an ethical regulatory landscape. These factors can vary significantly across health care ecosystems, dictating the choice of a particular LLM implementation pathway.
View Article and Find Full Text PDFChildhood obesity is a global health concern that has its origins before birth. Although genetics plays a crucial role, increasing evidence suggests that epigenetic modifications during fetal life could also influence its incidence. In this model, during the fetal period, interactions between genetic makeup, intrauterine factors, and environmental conditions, increase the risk of childhood obesity.
View Article and Find Full Text PDFExpanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases.
J Enzyme Inhib Med Chem
December 2024
The HECT E3 ubiquitin ligases 1 (WWP1) and 2 (WWP2) are responsible for the ubiquitin-mediated degradation of key tumour suppressor proteins and are dysregulated in various cancers and diseases. Here we expand their limited inhibitor space by identification of NSC-217913 displaying a WWP1 IC of 158.3 µM (95% CI = 128.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how the structure of a malonamide extractant in liquid-liquid extraction affects its water extraction performance, focusing on weak interactions that make structural identification difficult.
- Using small angle X-ray scattering (SAXS), the researchers find no major changes in structure after water is introduced, indicating that water interacts with the extractant to form simple 1:1 adducts without significant reorganization of the solution.
- Findings suggest that the extraction mechanism remains consistent across various extractant concentrations, with the process being straightforward and driven by fundamental interactions rather than complex structural changes like micellization.
Trial Design: Older adults experience chronic dysregulation of leukocytes and inflammatory cytokines, both at rest and in response to resistance training. Systemic hypoxia modulates leukocytes and cytokines, therefore this study characterized the effects of normobaric hypoxia on the leukocyte and cytokine responses of older adults to resistance training.
Methods: 20 adults aged 60-70 years performed eight weeks of moderate-intensity resistance training in either normoxia or normobaric hypoxia (14.