Method of kinetic characterization of immunoreagents for development of express high-sensitive assays for detection of ochratoxin A and heart fatty acids binding protein.

Development of rapid and sensitive immunoassays is a task of great importance in a variety of fields ranging from clinical practice and urgent diagnostics to food quality control and environmental monitoring. High attention of researches is paid to methods of screening, selection, and kinetic characterization of antibodies that enable fast, specific, and effective formation of immunocomplexes. Herein, we present a method for direct investigation of kinetics of immunoreagents during developments of express high sensitive lateral flow assays.

[Pericarditis in contemporary therapeutic clinic: nosological spectrum, approaches to diagnosis and treatment].

Aim: To analyze the register of pericarditis in a therapeutic clinic, to evaluate their nosological spectrum, to optimize approaches to diagnosis and treatment.

Materials And Methods: For the period 20072018, the register includes 76 patients with the diagnosis of pericarditis (average age 53.115.

Data on characterization of glass biochips and validation of the label-free biosensor for detection of autoantibodies in human serum.

The data represent in-depth characterization of a novel method for highly sensitive simultaneous measuring in human serum of both critical parameters of autoantibodies: concentration and native kinetics. The latter refers to autoantibody interaction with free, not immobilized, antigen. The method and related biosensors are based on the spectral-correlation and spectral-phase interferometry.

Evaluation of occupationally conditioned and non-occupational risks of health disorders in truck drivers.

The authors present analysis of changes in genera! morbidity related to age and length of service for truck drivers (chronic diseases of cardiovascular system, respiratory and digestive organs, urinary system, spine, locomotory system and connective tissue) exposed to complex combination of occupational hazards (unusual work schedule, night shifts, air pollution with automobile transport exhaust gases). Morbid "ity parameters were calculated according to deep medical investigation results in periodic examinations of drivers and their appealability to medical office. General hygienic evaluation of work conditions was performed according to increment in risk of diseases for length of service years (annual risk increase).

[THE AGE AND WORK EXPERIENCE DYNAMICS OF INDICES OF HEALTH OF EMPLOYEES--CRITERIA FOR COMPARISON OF OCCUPATIONAL AND NONOCCUPATIONAL RISKS].

There are reported data of the analysis of parameters of the general morbidity (hypertension, chronic diseases, organs of respiratory and digestive system, adiposity, vertebral osteochondrosis) in dependence on age and work experience of dockers-mechanizators in seaport at various working conditions. Morbidity rate indices were calculated on results of the profound medical examination at annual periodic surveys of workers. There were analyzed ecological and ergonomic indices of working conditions, including an estimation of physiological intensity of the work.