Cell line-based models of normal and chronic bronchitis-like airway mucosa to study the toxic potential of aerosolized palladium nanoparticles.

Background: Physiologically relevant cell line-based models of human airway mucosa are needed to assess nanoparticle-mediated pulmonary toxicity for any xenbiotics expsoure study. Palladium nanoparticles (Pd-NP) originating from catalytic converters in vehicles pose health risks. We aimed to develop airway models to assess the toxic potential of Pd-NP in normal (Non-CB) and chronic bronchitis-like (CB-like) mucosa models.

Insights into emulsion synthesis of self-assembled suprastructures formed by Janus silica particles with -NH/-SH surface groups.

Spherical particles with tunable anisotropic structures enabled by multiple surface functionalities have garnered interest for their potential applications in adsorption technologies. The presence of diverse functional groups in the surface layer, exhibiting varying acidity and hydrophilicity, can lead to unique characteristics in terms of surface structure and behaviour. In this study, the particles were synthesised using a two-step approach involving surface functionalisation of previously synthesised SiO Stöber particles.

Biphasic water-oil systems for functional augmentation of probiotic nanoencapsulated in luteolin-Fe shells.

Single-cell nanoencapsulation (SCNE) has great potential in the enhancement of therapeutic effects of probiotic microbes. However, the material scope has been limited to water-soluble compounds to avoid non-biocompatible organic solvents that are harmful to living cells. In this work, the SCNE of probiotic with water-insoluble luteolin and Fe ions is achieved by the vortex-assisted, biphasic water-oil system.

Natural Silicates Encapsulated Enzymes as Green Biocatalysts for Degradation of Pharmaceuticals.

Biocatalytic degradation with the use of enzymes has gained great attention in the past few years due to its advantages of high efficiency and environmental friendliness. Novel, cost-effective, and green nanoadsorbents were produced in this study, using natural silicates as an enzyme host matrix for core-shell immobilization technique. With the natural silicate as a core and silica layer as a shell, it was possible to encapsulate two different enzymes: horseradish peroxidase (HRP) and laccase, for removal and degradation of three pharmaceuticals: diclofenac (DFC), carbamazepine (CBZ), and paracetamol (PC).