Publications by authors named "G A Sciorelli"
Article Synopsis
- The study compares platelet activation levels in donor apheresis using two different devices: Trima and Spectra, focusing on plasma-reduced plateletpheresis.
- Results indicated that platelet collections from Trima had reduced aggregation response and lower P-selectin release post-stimulation, whereas differences vanished with traditional nonplasma-reduced procedures.
- The findings suggest multicomponent collection may lead to increased platelet activation, highlighting the need for further clinical studies to determine the implications of this on donor health and product efficacy.
Article Synopsis
- The study analyzed lymphocyte subsets in 20 packed red blood cell units before and after using the Pall Leukotrap RC inline filter system, dividing samples into two groups based on preparation methods.
- Group A (low spin/PRP removal) had significantly higher median white blood cell (WBC) counts compared to Group B (high spin/plasma and buffy-coat removal), with p < 0.0001 indicating a strong statistical difference.
- After filtration, lymphocyte counts, especially CD3+, CD3+CD4+, and CD3+CD8+ subsets, were reduced significantly, with all CD19+ lymphocytes dropping below the limit of detection in all units.
Background And Objectives: Extracorporeal circuits made of artificial substances may induce blood cells and humoral activation. Negatively charged surfaces may activate Factor XII and the prekallikrein-kinin cascade, resulting in bradykinin (BK) production. BK has been considered to be involved in severe hypotensive reactions occurring during therapeutic apheresis in patients taking angiotensin-converting enzyme (ACE) inhibitors or in those receiving platelet transfusion.
View Article and Find Full Text PDFBackground: The importance of transfusing WBC-reduced blood components is widely recognized, as it reduces the risk of alloimmunization and transfusion-transmitted CMV infections. The latest generation of cell separators allows the collection of WBC-reduced apheresis platelet concentrates (APCs).
Materials And Methods: Consecutive APCs (n = 232) were retrospectively evaluated: 163 collected with the Spectra LRS [leukocyte-reduction system] Version 5.