[Analysis of nuclear families with two or more patients with insulin-dependent diabetes mellitus with diabetic siblings].

HLA haplotype distribution was analyzed in nuclear families of patients with insulin-dependent diabetes mellitus. Sixteen families with two or more diabetic siblings were examined, a total of 69 subjects, 33 of these diabetic siblings and 36 normal subjects (siblings and parents). The data were processed using the involved sibling pairs method based on a mixed model making use of a conditional probability approach.

[Myocardial function in patients with type I diabetes mellitus].

Myocardial contractility was examined in patients with type I diabetes mellitus without coronary disease by selective tolerance test with transesophageal heart stimulation using doppler cardiography. Nineteen diabetics aged 17 to 36 with the disease duration from 0 to 20 years were examined. Maximal ejection time before and after the test was assessed.

[Lipid peroxidation and antioxidant enzymatic defense in patients with newly detected insulin-dependent diabetes mellitus].

Studies of lipid peroxidation and antioxidant enzymic defense in red cell membranes in 23 patients with newly detected insulin-dependent diabetes mellitus have revealed a statistically significant (2-fold) elevation of malonic dialdehyde lipid peroxidation products and a trend to a rise in the levels of lipid peroxides. This is parallelled by a certain overstrain of the cellular antioxidant defense system. The authors discuss the usefulness of administering antioxidant therapy at the onset of the disease in order to prevent the toxic injury of beta-cells and vascular endothelium cells by lipid peroxidation products.