Environmental Mixtures Analysis (E-MIX) Workflow and Methods Repository.

Human exposure to complex, changing, and variably correlated mixtures of environmental chemicals has presented analytical challenges to epidemiologists and human health researchers. There have been a wide variety of recent advances in statistical methods for analyzing mixtures data, with most of these methods having open-source software for implementation. However, there is no one-size-fits-all method for analyzing mixtures data given the considerable heterogeneity in scientific focus and study design.

Close-Up on Ambulance Service Estimation in Indonesia: Monte Carlo Simulation Study.

Background: Emergency medical services have a pivotal role in giving timely and appropriate responses to emergency events caused by medical, natural, or human-caused disasters. To provide adequate resources for the emergency services, such as ambulances, it is necessary to understand the demand for such services. In Indonesia, estimates of demand for emergency services cannot be obtained easily due to a lack of published literature or official reports concerning the matter.

Brief Report: Methylation-Based ctDNA Serial Monitoring Correlates With Immunotherapy Response in NSCLC.

Purpose: Circulating tumor DNA (ctDNA) can reflect the genetic and epigenetic composition of malignancies and can serve as a noninvasive biomarker for cancer diagnostics and monitoring. This study aimed to evaluate the utility of a methylation-based ctDNA assay as a predictive tool in non-small cell lung cancer (NSCLC) anti-PD1 based immunotherapy monitoring.

Methods: We evaluated a cohort of 20 patients with NSCLC treated with anti-PD1 based immunotherapy that had both baseline and follow-up blood draws as well as outcome data available.

Reducing wavelength jitter in white-light seeded femtosecond optical parametric chirped-pulse amplifiers.

White light generation (WLG) in bulk material can be used as a versatile broadband seed source for optical parametric chirped pulse amplification (OPCPA) stages. In this case, it is beneficial to optimize the performance of the WLG seeder in combination with the subsequent OPCPA stage. Here, we characterize how small variations in the drive pulse energy affect the white light seeder performance, in particular the wavelength stability of the amplified OPCPA spectrum.

In vitro vascularization improves in vivo functionality of human engineered cardiac tissues.

Engineered human cardiac tissues hold great promise for disease modeling, drug development, and regenerative therapy. For regenerative applications, successful engineered tissue engraftment in vivo requires rapid vascularization and blood perfusion post-implantation. In the present study, we engineered highly functional, vascularized cardiac tissues ("cardiopatches") by co-culturing human induced pluripotent stem cell-derived cardiomyocytes (hiPSCCMs) and endothelial cells (hiPSC-ECs) in optimized serum-free media.