Publications by authors named "G A Ouedraogo"
Objective: This study aimed to evaluate the immune response in people fully vaccinated against hepatitis B with the GeneVac-B vaccine in Burkina Faso under actual conditions of use.
Methods: This cross-sectional study included individuals fully vaccinated with GeneVac-B. For each consenting participant, sociodemographic and clinical data were collected using a structured questionnaire.
White matter alterations are increasingly implicated in neurological diseases and their progression. International-scale studies use diffusion-weighted magnetic resonance imaging (DW-MRI) to qualitatively identify changes in white matter microstructure and connectivity. Yet, quantitative analysis of DW-MRI data is hindered by inconsistencies stemming from varying acquisition protocols.
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- Trypanosome parasites are responsible for African animal trypanosomosis, a serious disease affecting livestock in sub-Saharan Africa, and interact directly with the host's immune system.
- Understanding the immune response in cattle, which are significantly impacted by this disease, is essential for developing effective control strategies.
- This review highlights the current state of knowledge on bovine immune responses to trypanosomosis, including infection processes, trypanotolerance, and key immune regulatory mechanisms, while also identifying critical areas that need more research.
In vitro pharmacologic profiling aids systemic toxicity assessment of chemicals.
Toxicol Appl Pharmacol
November 2024
Article Synopsis
- An adapted in vitro pharmacology profiling panel (APPP) was created to evaluate the effects of 129 cosmetic chemicals, including both traditional pharmaceutical targets and additional targets related to systemic toxicities.
- The study demonstrated strong internal data consistency, with reproducible results across different testing concentrations and compatibility with existing ToxCast and drug excipient data.
- The findings highlight how this panel can aid in risk assessments for cosmetic chemicals without the need for new animal testing, supported by case studies and discussions of new methodologies.
Introduction: Klebsiella pneumoniae is an encapsulated Gram-negative bacterium that is responsible for numerous infections in healthcare facilities worldwide and is frequently isolated. The World Health Organization has listed K. pneumoniaeas as a critical antibiotic resistant bacterial pathogen for which new antibiotics are urgently needed.
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