[The activity of redox-regulatory systems in the primary and recurrence tumors in vulvar cancer].

The activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione reductase (GR), glutathione transferase (GST), the content of reduced glutathione (GSH) and malondialdehyde (MDA) were investigated in the samples of the tumor, peritumoral zone and healthy tissue, taken at the line of resection, were obtained from 14 patients with primary squamous cell carcinoma of the vulva, and 13 patients with local recurrence appeared in the period from 3 months to 7 years. by conventional spectrophotometric methods. The content of GSH and the activity of SOD, GPx, GR, GST were significantly increased, while MDA was decreased in the tissue of the primary carcinoma of the vulva in compared with the healthy tissue.

[The activity of redox-regulatory systems in the tumor and its surrounding tissues in various histological types of tumor].

According to modern concepts cancer is a complex dynamic system having multiple relationships with both the immediate environment and with remote nonmalignant tissues and organs. Changes in the redox balance in them can result in disruption of the normal tissue control. Understanding of the biology of redox processes in a particular tumor and its surroundings, and of their functioning mechanisms is necessary for the development of new anti-cancer strategies based on the effects on the redox state of the tumor and surrounding tissue.

[The level of endogenous intoxication iт oncologic gynecologic patients.].

The leading role of syndrome of endogenous intoxication in structure of clinical manifestations of tumor disease conditions actuality of studying components determining its development, in dynamics of malignant process and under anti-tumor therapy. Among all studied groups of oncogynecological patients, the most expressed decreasing of functional activity of albumin binding toxic compounds is observed under ascitic form of ovary cancer. In the group of patients with ovary cancer of stage I-II and also in condition of remission of process in patients with ovary cancer of stage III, the values of total and effective concentration of albumin and its binding capacity, on the contrary, are approaching to donor values.

[Informative value of the VCS parameters of peripheral blood neutrophils in the evaluation of status of patients with recurrent and metastatic cervical cancer].

The total values of white blood cells (WBC), the absolute and relative neutrophil counts, neutrophil VCS parameters: MVNe (volume), MCNe (conductivity), and MSNe (light scattering) were studied in 70 patients with recurrent and metastatic cancer of the cervix uteri, by using a LH-500 hematology analyzer (Beckman Coulter). The blood from 35 apparently healthy women served as a control. The magnitude of changes in MVNe and in the intensity of MSNe was found to increase in patients when the level of WBC and the content of neutrophils were elevated.

[Endogenous factors in the pathogenesis of vulvar cancer].

In 59 patients with cancer of the vulva, levels of ACTH, FSH, thyrotropin, prolactin, somatotropin, cortisol, triiodothyronine, thyroxin, testosterone, progesterone and estradiol were measured in blood whereas those of 17-HOCS, 17-CS and estrogens--in urine. Hormonal imbalance was established at all levels of the endocrine system, viz. increased concentrations of cortisol and 17-HOCS, decreased ACTH level, shift in androgen/estrogen and androgen/progestin ratios towards testosterone, lowered FSH and somatotropin output and elevated blood-prolactin level.