The effects of low-dose morphine on sleep and breathlessness in COPD: A randomized trial.

Background: Low-dose morphine may be prescribed to reduce chronic breathlessness in chronic obstructive pulmonary disease (COPD). Recent subjective findings suggest morphine may influence breathlessness through sleep-related mechanisms. However, concerns exist regarding opioid safety in COPD.

Rural drinking water supply program and societal development: Evidence from the early implementation phase of India's Jal Jeevan Mission.

With a community-centric approach to achieve Sustainable Development Goal 6.1, the Jal Jeevan Mission (JJM) launched in 2019, aims to improve the living standard of rural communities by addressing various issues related to rural drinking water supply system. The literature evaluating rural water supply programs in India is sparse.

Thermal imaging through hot emissive windows.

It is not currently possible for an infrared camera to see through a hot window. The window's own blinding thermal emission prevents objects on the other side from being imaged. Here, we demonstrate a path to overcoming this challenge by coating a hot window with an asymmetrically emitting infrared metasurface whose specially engineered imaginary index of refraction produces an asymmetric spatial distribution of absorption losses in its constituent nanoscale resonators.

Understanding the chemistry & pharmacology of antibody-drug conjugates in triple-negative breast cancer with special reference to exatecan derivatives.

In the spectrum of breast malignancies, triple-negative breast cancer is the most widely spreading subtype of breast cancer due to a low availability of therapeutic remedies. Recently, antibody-drug conjugates dramatically resolved the landscape for the treatment of triple-negative breast cancer. This review mainly focuses on the chemistry, structure, mechanism of action, and role of antibody-drug conjugates in triple-negative breast cancer.