Publications by authors named "G A Nai"
Introduction: 2,4-dichlorophenoxyacetic acid (2,4-D) is one of the most used in the world and exposure to herbicides can affect animals and humans, causing toxic effects that include cardiotoxicity. This is the first study to evaluate cardiac remodeling after experimental simulation of environmental exposure by chronic inhalation (6 months) to the herbicide 2,4-D.
Methods: Thirty male Wistar rats were exposed to two different concentrations of the 2,4-D formulation (low - 187.
Background: Soil salinity is an important environmental component affecting plant growth and yield, but high-salinity soils are a major constraint to the development of the grape industry. Previous studies have provided lines of evidence that gibberellins (GAs) play a significant regulatory role in plant responses to salt stress. However, it remains unclear whether GA2ox, a key enzyme that maintains the balance of bioactive gibberellins and intermediates in plants, is involved in the mechanism of salt stress tolerance in grapes.
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- Glyphosate-based herbicides (GBHs) are widely used in agriculture, but their neurotoxic effects are not fully understood.
- In a study with sixty male rats, different exposure methods (oral and inhalation) and concentrations of GBH were tested over six months to evaluate behavioral and biological impacts.
- Results showed that GBH exposure, especially at higher concentrations, led to increased anxiety levels, tissue hyperemia, and thicker cerebral cortex in rats, with varying effects depending on the exposure route.
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- Acute myeloid leukemia (AML) is linked to the abnormal activation of the JAK/STAT3 signaling pathway, which can be targeted for treatment.
- Previous research showed that SAR317461, a new JAK2/STAT3 inhibitor, effectively reduces AML cell activity and promotes cell death.
- This project aims to improve SAR317461's delivery to AML cells using CD34 antibody-modified liposomes, enhancing treatment effectiveness by combining it with cytarabine and potentially tackling chemotherapy resistance.
The WUSCHEL-related homeobox (WOX) transcription factor family plays critical roles in plant growth, development, and stress adaptation, but the biological functions in response to various stress of the WOX gene family have not been extensively researched in grapevine (Vitis vinifera ). In this study, 12 grapevine WOXs were identified from the grapevine genome. Quantitative PCR and microarray expression profiling found that the expression of WOXs had an obvious tissue-specific pattern.
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