[Characteristics of the acidic extract from the epiphysis and its fractions].

Acid extract of bovine epiphyses was separated by means of gel filtration on Sephadex G-50 into two fractions: high and low molecular preparations. Estimation of biological activity of the acid extract and its polypeptide fractions, which was carried out using the procedure of antigonadotropic effect on preadolescent rat females, showed that the antigonadotropic effect was distinctly higher in the preparation free of high molecular substances.

[Methodological characteristics of the preclinical study of the safety of drug preparations for children].

Some aspects of the preclinical study on safety of drugs used in children during experiments on immature animals are presented. Problems of the selection of animal species and the experimental schemes are discussed.