Publications by authors named "G A Mulder"
There is overwhelming preference for application of the unphysiologic, well-stirred model (WSM) over the parallel tube model (PTM) and dispersion model (DM) to predict hepatic drug clearance, , despite that liver blood flow is dispersive and closer to the DM in nature. The reasoning is the ease in computation relating the hepatic intrinsic clearance ( ), hepatic blood flow ( ), unbound fraction in blood ( ) and the transmembrane clearances ( and ) to for the WSM. However, the WSM, being the least efficient liver model, predicts a lower that is associated with the in vitro ( / ), therefore requiring scale-up to predict in vivo.
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- Heart failure admissions pose significant challenges, and early detection of fluid retention is crucial for effective intervention.
- A study of 92 adult patients used a Triage-HF algorithm in implanted heart devices to monitor health, achieving high accuracy rates: 83% sensitivity and 97% specificity for identifying fluid issues.
- The majority of high-risk alerts led to increased diuretic treatment, with a relatively low rate of unnecessary hospitalizations and quick response times from healthcare professionals.
From July 2020 to June 2021, 248 wild house mice (Mus musculus), deer mice (Peromyscus maniculatus), brown rats (Rattus norvegicus), and black rats (Rattus rattus) from Texas and Washington, USA, and British Columbia, Canada, were tested for SARS-CoV-2 exposure and infection. Two brown rats and 11 house mice were positive for neutralizing antibodies using a surrogate virus neutralization test, but negative or indeterminate with the Multiplexed Fluorometric ImmunoAssay COVID-Plex, which targets full-length spike and nuclear proteins. Oro-nasopharyngeal swabs and fecal samples tested negative by RT-qPCR, with an indeterminate fecal sample in one house mouse.
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- The retinal therapeutics field has significantly evolved since the first anti-VEGF therapy was approved in 2004, with a focus on a variety of retinal diseases and improved treatment options, resulting in nearly $10 billion in investments over two decades.
- Treatments have shifted from competing against anti-VEGF therapies to finding ways to reduce patient treatment burden, alongside new initiatives targeting conditions like dry AMD and Retinitis pigmentosa.
- The review highlights successful drug approvals, ongoing challenges, investment dynamics, and future strategies in retinal therapeutics, including innovative approaches like cell-based therapies and gene editing.
Rodents used in biomedical research are maintained as specific pathogen-free (SPF) by employing biosecurity measures that eliminate and exclude adventitious infectious agents known to confound research. The efficacy of these practices is assessed by routine laboratory testing referred to as health monitoring (HM). This study summarizes the results of HM performed at Charles River Research Animal Diagnostic Services (CR-RADS) on samples submitted by external (non-Charles River) clients between 2003 and 2020.
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