Publications by authors named "G A Miana"
Article Synopsis
- - The study focuses on developing herbal tablets from Saussurea heteromalla, examining their potential as anti-cancer treatments, particularly against cervical cancer.
- - Arctigenin was identified as a key anti-cancer compound, with in vitro tests showing effectiveness on HeLa cells, supporting the traditional use of S. heteromalla in Chinese medicine.
- - The herbal tablets demonstrated good stability and drug release characteristics, with over 87% of the active ingredient being released in one hour, indicating their potential for future anti-cervical cancer therapies pending further testing.
Objectives: The study was aimed at synthesis of the new derivatives of the pyrazolone nucleus, and their spectroscopic and pharmacological analysis and evaluation.
Materials And Methods: Three series of compounds, with 2-picolinic acid (I a-d), 3-picolinic acid (II a-d), and 4-picolinic acid (III a-d) were synthesized and characterized by FT-IR, 1HNMR, 13C NMR, elemental, and melting points. The new compounds were then evaluated for their anti-oxidant, anti-inflammatory, and anti-epileptic potential.
Alzheimer's disease (AD), a relentless neurodegenerative disorder, is still waiting for safer profile drugs, risk factors affecting AD's pathogenesis include aβ accumulation, tau protein hyperphosphorylation, and neuroinflammation. This research aimed to synthesize 2-amino-6‑trifluoromethoxy benzothiazole schiff bases. Synthesis was straightforward, combining the riluzole skeleton with compounds containing the azomethine group.
View Article and Find Full Text PDFBackground: Cardiac magnetic resonance (CMR) is a unique tool for non-invasive tissue characterization, especially for identifying fibrosis.
Aim: To present the existing data regarding the association of electrocardiographic (ECG) markers with myocardial fibrosis identified by CMR - late gadolinium enhancement (LGE).
Methods: A systematic search was performed for identifying the relevant studies in Medline and Cochrane databases through February 2021.
Article Synopsis
- Saussurea heteromalla, a member of the Asteraceae family, is commonly found in Pakistan and shows promise in biological research, particularly for its potential anti-inflammatory, antioxidant, and anti-cancer properties.
- The study involves various assays, including carrageenan-induced rat paw edema for anti-inflammatory effects, DPPH for antioxidant activity, and the MTT test to evaluate cell viability and cytotoxicity of the methanolic extract.
- Results indicate that the methanolic extract of Saussurea heteromalla exhibits significant anti-inflammatory and antioxidant effects, with a notable cytotoxic effect at higher doses, suggesting the need for further isolation and exploration of its active compounds.