Publications by authors named "G A Margolin"
Defects in DNA single-strand break repair are associated with neurodevelopmental and neurodegenerative disorders. One such disorder is that resulting from mutations in , a scaffold protein that plays a central role in DNA single-strand base repair. XRCC1 is recruited at sites of single-strand breaks by PARP1, a protein that detects and is activated by such breaks and is negatively regulated by XRCC1 to prevent excessive PARP binding and activity.
View Article and Find Full Text PDFBackground: The complexity and heterogeneity of neutrophils are recognized, especially their roles in modulating inflammation and cancer immune responses. The detailed functions of neutrophils in human tumour-draining lymph nodes (TDLNs), specifically in the context of head and neck cancer, remain inadequately characterized.
Aim: This study aims to delineate the phenotypic diversity of neutrophils in TDLNs, non-tumour-draining lymph nodes (nTDLNs) from patients with oral squamous cell carcinoma (OSCC), and to evaluate their correlation with clinical outcomes.
Article Synopsis
- OSCC recurrence and mortality rates remain high despite various treatments, highlighting the need for improved prognostic models and biomarkers, particularly focusing on tumor-draining lymph nodes (TDLNs) and T regulatory cells (Tregs).
- A study of 49 OSCC patients found that certain immune cell markers in TDLNs, like elevated FoxP3+CD4+ and TIGIT+CD8+ cells, were linked to worse disease-free survival, while high levels of CXCR5+CD4+ cells indicated better outcomes.
- The research suggests that the expression of immune checkpoints on T cells within TDLNs could serve as critical prognostic biomarkers, pointing towards the potential benefits of using neoadjuvant immunotherapy to enhance
Background: Radiotherapy is a well-established treatment for lip cancer, with external radiotherapy (EBRT) or brachytherapy (BT).
Methods: This study evaluated outcome, tumor control, and aesthetics, for 101 patients with carcinoma of the lip, not suitable for surgery, treated with combined EBRT and BT.
Results: Squamous cell carcinoma was seen in 78 patients, basal cell carcinoma in 15, and other histologies in 8 patients.
Article Synopsis
- Oral squamous cell carcinoma (OSCC) has a better survival rate when detected early, but prognosis worsens if it spreads to lymph nodes; identifying biomarkers for early detection could improve treatment strategies.
- The study analyzed dendritic cells and T-cells in tumor-draining lymph nodes from 12 OSCC patients and compared them to 9 benign cases, revealing that certain immune cells in TDLNs show immunosuppressive characteristics and are linked to metastasis.
- Findings suggest that high PD-L1 expression on dendritic cells in TDLNs may indicate metastatic risk and poorer outcomes, positioning PD-L1 as a potential predictive biomarker for OSCC prognosis.