[Nitric oxide metabolism in the inclusion of N-acetylcysteine into the complex therapy of patients with community-acquired pneumonia].

Thirty-five patients with community-acquired pneumonia were examined. Studies of red blood cells and expired air condensate revealed significant nitric oxide metabolic disturbances in them. In a group of 17 patients, the use of N-acetylcysteine in the complex therapy resulted in the normalization of most parameters that characterized nitric oxide metabolism (nitrates, nitrites, peroxynitrite, NADP-H-diaphorase, and nitrate reductase activity).

[Pathogenetic aspects of hemolysis and changes of blood rheology in hereditary hemochromatosis].

Aim: To establish changes of and correlations between erythrodieresis and blood rheology in hereditary hemochromatosis (HHC).

Materials And Methods: Hemorheologic indices (asymptomatic blood and plasma viscosity, that of blood at low shift speed, red cell deformity and aggregation) were studied in 42 HHC patients and 23 healthy donors. The patients were divided into groups by homozygous (groups 1 and 2) or heterozygous (groups 3 and 4) allel genes and sex (females-groups 2 and 4, males-groups 1 and 3).

[The distribution of aspartate aminotransferase activity in the structures of the visual analyzer in the canine brain during postnatal ontogeny].

Studies have been made on aspartate aminotransferase activity in light and heavy synaptosomes, membrane and synaptic mitochondria from the visual cortex (field 17), bigeminal bodies, and outer geniculate body. It was shown that the enzymic activity significantly decreases in all the subfractions investigated in puppies beginning from 6 months up to 1 year. In earlier postnatal ontogenesis, the activity increased in all the subfractions, the extent of the increase being dependent on the source of the enzyme.

[Nephrogenic mechanism of post-traumatic hemolysis].

The crush-syndrome model was introduced for experimental evaluation of the kidney-related mechanism of red cell destruction in an early posttraumatic period (1 day). Absolute and relative counts of the red cells, HCT were found reduced, while serum hemoglobin was on the increase in rats with crush syndrome against the controls and rats subjected to trauma and nephrectomy. Renal perfusion in situ with syngeneic blood brought about a decline in rat erythrocyte functional performance and a rise in the level of free hemoglobin.