Publications by authors named "G A Kotov"
Multiple sclerosis (MS) is a chronic neurodegenerative disorder involving demyelination. The cuprizone model is commonly used to study MS by inducing oligodendrocyte stress and demyelination. The subventricular zone (SVZ) plays a key role in neurogenesis, while the neuronal/glial antigen 2 (NG2) is a marker for immature glial cells, involved in oligodendrocyte differentiation.
View Article and Find Full Text PDFBackground: Arterial hypertension is a primary risk factor for kidney disease. Recent advances have implied a potential link between the apelin system and renal homeostasis.
Materials And Methods: We used 6- and 12-month-old spontaneously hypertensive rats and age-matched normotensive controls to assess the changes in the renal expression of the apelin receptor by immunohistochemical method.
Angiogenesis, the natural mechanism by which fresh blood vessels develop from preexisting ones, is altered in arterial hypertension (AH), impacting renal function. Studies have shown that hypertension-induced renal damage involves changes in capillary density (CD), indicating alterations in vascularization. We aimed to elucidate the role of the apelin receptor (APLNR), neuronal nitric oxide synthase (nNOS), and vascular endothelial growth factor (VEGF) in hypertension-induced renal damage.
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- Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation in joints and can lead to a decline in mobility and overall quality of life, but the exact cause remains unclear.
- Genetic, environmental, and lifestyle factors contribute to susceptibility to RA, with certain genetic markers indicating a higher risk for developing the disease.
- Recent studies highlight the significance of the microbiome in influencing immune responses, where changes in microbial composition (dysbiosis) may trigger chronic inflammation and play a crucial role in the development and progression of RA.
Systemic necrotising vasculitides (SNVs) pose significant challenges due to their diverse clinical manifestations and variable outcomes. Therefore, identifying reliable biomarkers holds promise for improving precision medicine in SNVs. This review explores emerging biomarkers aiming to enhance diagnostic accuracy, prognostic assessment, and disease monitoring.
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