Identification of a novel HLA-DQB1 allele, DQB1*05:19, in an African American family by sequence-based typing.

The novel allele, DQB1*05:19, differs from the closest matching allele, DQB1*05:02:01, by one nucleotide substitution.

Identification of a novel HLA-DRB1 allele, DRB1*09:20, by sequence-based typing in an unrelated bone marrow donor.

The novel allele HLA-DRB1*09:20 differs from HLA-DRB1*09:01:02 by one nucleotide substitution at codon 9 (AAG->CAG) and differs from HLA-DRB1*09:07 by one nucleotide substitution at codon 13 (TAT->TTT).

Identification of a novel HLA-A*680202 allele by sequence-based typing in an African American individual.

The new HLA-A*680202 differs from HLA-A*680201 by one synonymous nucleotide substitution at position 618 (ACG --> ACT).

Identification of a novel HLA-C allele, Cw*021602, by sequence-based typing in a family of German descent.

The novel allele HLA-Cw*021602 differs from HLA-Cw*021601 by a nuecleotide substitution at condon 162 (ACG to ACA).

Effect of desensitization in solid organ transplant recipients depends on some cytokines genes polymorphism.

Desensitization (DS) is widely used to decrease PRA in solid organs transplant candidates (TC). Various numbers of cycles of DS are required to reduce or eliminate donor specific antibodies (DSA). The goal of this study was to investigate if there was a correlation between polymorphism (PM) of some cytokine genes and intensity of DS required to make the recipient/donor cross match compatible.