Publications by authors named "G A Hackett"
Article Synopsis
- * The TRAVERSE study, published in June 2023, found no increased risk of major cardiovascular events in men receiving testosterone therapy compared to a placebo, countering earlier studies that suggested potential risks.
- * Based on the TRAVERSE findings and extensive previous research, the Androgen Society concludes that testosterone therapy is not linked to higher risks of heart attacks, strokes, or cardiovascular deaths.
Article Synopsis
- The study examined the relationship between seasons and variations in serum testosterone levels in a group of 144 men, analyzing various seasonal environmental factors.
- Results showed no significant differences in testosterone levels or associations with seasonal changes, although a slight inverse correlation was found between temperature, daylight, and testosterone in non-fasting men.
- The findings suggest that seasonal factors may not significantly impact serum testosterone levels, which could help clarify variables affecting clinical practices and laboratory results.
Long Term Cardiovascular Safety of Testosterone Therapy: A Review of the TRAVERSE Study.
World J Mens Health
August 2024
Article Synopsis
- TRAVERSE was a large clinical trial examining the effects of testosterone therapy on men aged 45-80 with hypogonadism and cardiovascular disease risk, involving 5,246 participants.
- Participants were randomly assigned to receive either a testosterone gel or a placebo for an average of 27.1 months, while monitoring their cardiovascular health.
- The study concluded that testosterone therapy did not increase the risk of major adverse cardiovascular events or prostate-related issues, alleviating concerns previously raised by the FDA.
Objective: We evaluated change (Δ) in AMSS in men with adult-onset testosterone deficiency (TD) on/not on testosterone undecanoate (TU) by analysing a registry of men with adult-onset TD.
Methods: Analyses were performed using non-parametric statistics to determine ΔAMSS at 6-12 monthly intervals in men on/not on TU and movement in AMSS. Factors predicting ΔAMSS were established linear/multiple regression.
Testosterone Replacement Therapy: Effects on Blood Pressure in Hypogonadal Men.
World J Mens Health
October 2024
Purpose: While testosterone therapy can improve the various pathologies associated with adult-onset testosterone deficiency (TD), Summary of Product Characteristics (SPC) of five testosterone preparations caution that treatment may be associated with hypertension. This paper evaluates the impact of testosterone undecanoate (TU) on blood pressure (BP) in men with adult-onset TD.
Materials And Methods: Of 737 men with adult-onset TD in an on-going, observational, prospective, cumulative registry, we studied changes in BP using non-parametric sign-rank tests at final assessment and fixed time points.