Publications by authors named "G A Gusarova"
The lung's mechanosensitive immune response, which occurs when pulmonary alveoli are overstretched, is a major impediment to ventilation therapy for hypoxemic respiratory failure. The cause is not known. We tested the hypothesis that alveolar stretch causes stretch of alveolar macrophages (AMs), leading to the immune response.
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- Retinoids are crucial for regulating cell processes like proliferation and differentiation, particularly in the lung alveolus during inflammation.
- Research in male mice highlights the importance of local retinoid stores in lung health during an acute inflammatory response, specifically when exposed to lipopolysaccharide.
- The study reveals that not just lipofibroblasts, but also microvascular endothelial and alveolar epithelial cells, can accumulate retinoids and play significant roles in responding to inflammation.
Article Synopsis
- Acute Lung Injury (ALI) from inhaled pathogens leads to high mortality, and the mechanisms behind it are not well understood.
- Optical imaging studies in live mice reveal that the mitochondrial Ca uniporter (MCU) plays a crucial role in calcium buffering within alveolar type 2 cells, which is linked to surfactant secretion.
- Mice without MCU show severe lung damage and death after exposure to harmful substances, but providing surfactant beforehand helps protect against these effects, suggesting that boosting MCU function could be a potential treatment for ALI.