[Balance of steroid hormones among children and teenagers with epilepsies].

The level of steroid hormones (cortisol, cortisone, aldosterone) in children with epilepsy, aged from 4 to 18 years, was investigated. The levels of cortisol, cortisone and aldosterone were changed in 58.0%, 32.

[A simple method for determining antiepileptic preparations in biological fluids by using high-pressure liquid chromatography (HPLC)].

The authors suggest a simple HPLC method with ultraviolet detection at 200 nm for finding barbiturates, diphenine, etosuccimide, and carbamazepin in plasma and saline using an original technology of liquid-liquid extraction. It allows clear chromatograms with a minimal amount of interfering compounds, a high extraction percentage (90-100%) and sufficient sensitivity to be obtained. A method has also been worked out for detecting clonazepam on the basis of solid-phase extraction (cartridge "Diapak-C16") precolumn concentration, and ultraviolet detection at 200 and 215 nm.