Publications by authors named "G A Fritz"
The present study investigates the influence of nitrosamines and etoposide on mesenchymal stromal cells (MSCs) in a differentiation state- and biological age-dependent manner. The genotoxic effects of the agents on both neonatal and adult stem cell populations after treatment, before, or during the course of differentiation, and the sensitivity of the different MSC types to different concentrations of MNU or etoposide were assessed. Hereby, the multipotent differentiation capacity of MSCs into osteoblasts, adipocytes, and chondrocytes was analyzed.
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- Indigenous maize varieties from eastern North America have significantly influenced breeding programs, but their origins remain unclear.
- Paleogenomic studies trace maize's journey to this region, indicating multiple migrations from Mexico, especially towards the northern U.S., including a notable path from the Southwest.
- Analysis shows that ancient Ozark maize specimens exhibit a unique wx1 gene linked to starch metabolism, demonstrating how selective pressures shaped maize domestication and connecting these varieties to the Northern Flints, vital for today's commercial maize.
Article Synopsis
- * This study discovered specific nanobodies (Nbs) that target the common forms of S100B, which help regulate its interaction with RAGE, demonstrating strong binding to one of its functional forms.
- * Experimental results indicate that these Nbs can block the harmful interactions between S100B and RAGE, suggesting their potential as tools for understanding and treating conditions related to S100B in the nervous system.
The therapeutic efficacy of the anticancer drug cisplatin is limited by acquired drug resistance. Cisplatin forms DNA crosslinks, that, if not removed, lead to replication stress. Due to this, the DNA damage response (DDR) gets activated regulating cell cycle arrest, DNA repair, cell death or survival.
View Article and Find Full Text PDFBackground: Laparoscopic sleeve gastrectomy (LSG) is the most common bariatric surgery performed worldwide. The Titan stapler aims to standardize the sleeve gastrectomy by eliminating inconsistencies and simplifying the procedure.
Methods: A retrospective chart review was performed on all patients > 18 years of age undergoing LSG using the Titan.