Updating Primary Antibiotic Resistance in Helicobacter pylori Strains Isolated in Italy.

Background And Aims: Bacterial resistance toward the most used antibiotics is increasing in Helicobacter pylori (H. pylori) strains worldwide. The emergence of multidrug resistance significantly affects the efficacy of standard therapy regimens.

The Frequency and Main Characteristics of Obesity in Undocumented Migrants Receiving Medical Assistance from a Charitable Organisation in Italy.

Background: Obesity is continually growing not only in medium- and high-income countries but also in low-income countries, from where increasing numbers of migrants arrive in Western countries. We aimed to investigate the frequency and characteristics of obesity in a sample of undocumented migrants, a population for which official health data are not available.

Methods: We collected demographic and socio-economic data and information on medical diagnoses and pharmacologic treatments for 341 undocumented migrants consecutively attending the outpatient clinic of a big non-governmental organisation in Milan, Italy, from March to July 2023.

Using large language models to detect outcomes in qualitative studies of adolescent depression.

Objective: We aim to use large language models (LLMs) to detect mentions of nuanced psychotherapeutic outcomes and impacts than previously considered in transcripts of interviews with adolescent depression. Our clinical authors previously created a novel coding framework containing fine-grained therapy outcomes beyond the binary classification (eg, depression vs control) based on qualitative analysis embedded within a clinical study of depression. Moreover, we seek to demonstrate that embeddings from LLMs are informative enough to accurately label these experiences.

Human prolyl hydroxylase domain 2 reacts with O and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes.

Hypoxia inducible transcription factors (HIFs) mediate the hypoxic response in metazoans. When sufficient O is present, Fe(II)/2-oxoglutarate (2OG)-dependent oxygenases (human PHD1-3) promote HIFα degradation via prolyl-hydroxylation. We report crystallographic, spectroscopic, and biochemical characterization of stable and inactive PHD2.