[Circulating complexes of plasma fibronectin (fibronectin-fibrin) in human diseases].

The study of circulating complexes fibronectin-fibrin in 21 patients with immunocomplex affections revealed their high levels which occurred in inverse relationships with fibronectin concentrations in the blood, but in direct correlation with indicators of inflammation (fibrinogen, cialic acid). It is suggested that the complexes are involved in the development of fibrosis at the sites of chronic inflammation in immune disorders.

[Erythrocyte equidistance and heavy metals in the pathogenesis of disseminated intravascular coagulation in myocardial infarct patients at the hospital rehabilitation stage].

Blood levels of fibrin degradation products and free haemoglobin were studied in 108 inpatients with acute transmural myocardial infarction in the period of rehabilitation. At the same time contents of cadmium, vanadium, lead and nickel in blood cells and plasma were determined spectrographically. It was established that heavy metals take part in activation of blood clotting and haemolysis which decrease equidistance and accelerates sedimentation of erythrocytes.

[The detection of preventive hypofibronectinemia in diagnosing the development of disseminated intravascular coagulation in patients with myocardial infarction at the hospital rehabilitation stage].

Postmyocardial infarction patients on hospital rehabilitation in case of no complications were examined for time course changes in the levels of fibrinogen degradation products (FDP), free hemoglobin (fHg) and fibronectin (Fn) using enzyme immunoassay. As shown by FDP and fHg values, the patients had DIC syndrome with its maximum on observation days 6-12 and 22-24. Fn fall occurred on the disease day 2-4 preceding maximum hemostasis activation up to 6-12th day.

[The content of ceruloplasmin, fibronectin and selenium in the blood of patients with an acute myocardial infarct].

The content of ceruloplasmin, fibronectin and selenium was evaluated in the blood plasma of acute myocardial infarction patients within the first three days after onset if the disease. Results showed a reduction of fibronectin during the first hours after onset of the disease. The content of ceruloplasmin was increased, selenium reduced during the entire period of examination indicating pronounced disturbances of lipid peroxidation in the acute period of myocardial infarction as well as potentiation of antioxidant processes.