An investigation of three suspected cases of pulmonary histoplasmosis among 600 employees at a New York prison in a nonendemic area resulted in identification of 12 additional previously unrecognized cases. The 15 cases presented with diagnostic findings between February 1978 and October 1981; 10 were in prison employees, three in inmates and two in community persons. Unlike other outbreaks, cases presented over several years with chronic pulmonary lesions in the absence of an episode marked by acute respiratory illnesses.
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