Publications by authors named "G A Cottrell"
Introduction: Asymptomatic malaria infection is now recognized as a potential threat to malaria control. However, its prevalence and its dynamics are poorly documented especially in a perennial context of high seasonal transmission. A longitudinal study was conducted in southern Benin to investigate the dynamics of asymptomatic malaria infection and to identify factors influencing it.
View Article and Find Full Text PDFArticle Synopsis
- Dengue is a viral infection spread by mosquitoes, and this study in Benin aimed to investigate the presence of different serotypes beyond the previously recorded DENV serotype 2.
- The research involved analyzing plasma samples from 464 patients for dengue infection using advanced PCR techniques, which led to the identification of DENV-1 and DENV-3 serotypes in three patients.
- This finding highlights the importance of enhancing arbovirus surveillance in Benin, indicating the need for better monitoring of emerging infections.
Objectives: We aimed to evaluate the impact of malaria declaration year (before or after 2017) on the frequency of hospitalization in metropolitan France of patients with uncomplicated non-vomiting P.falciparum malaria.
Patients And Methods: An observational, multicenter, retrospective study was carried out, using the database from the French National Reference Centre for Malaria.
Article Synopsis
- Regulatory T cells (Treg) are crucial for managing immune responses in newborns, especially regarding tolerance to maternal antigens and fighting infections at birth.
- This study, focusing on newborns in West Africa, found that neonates with early-onset sepsis (EOS) had reduced Treg frequency and expression of the Foxp3 marker compared to healthy newborns with prenatal risk factors, indicating a compromised immune profile.
- The findings suggest that specific Treg markers like CTLA-4, PD-1, and CD39 could serve as potential early diagnostic indicators for EOS, as their expression correlates with the severity and outcome of the condition.
Article Synopsis
- The study investigates SARS-CoV-2 seroprevalence among pregnant women in Benin, revealing that 75.7% of unvaccinated participants showed antibodies to the virus.
- Conducted in 2022 with 861 participants, the research identified spatial clusters of infection, highlighting that urban areas like Allada had higher concentrations of cases.
- Unvaccinated pregnant women with prior health issues were found to be at a significantly increased risk of SARS-CoV-2 infection, emphasizing the need for targeted health interventions.