A distal convoluted tubule-specific isoform of murine SLC41A3 extrudes magnesium.

Background: The distal convoluted tubule (DCT) plays an indispensable role in magnesium (Mg) reabsorption in the kidney. Yet, the extrusion mechanism of Mg has not been identified. The solute carrier 41A3 (SLC41A3) has been suggested to be involved in Mg extrusion, but this has never been conclusively demonstrated.

Galectin-9 regulates dendritic cell polarity and uropod contraction by modulating RhoA activity.

Adaptive immunity relies on dendritic cell (DC) migration to transport antigens from tissues to lymph nodes. Galectins, a family of β-galactoside-binding proteins, control cell membrane organisation, exerting crucial roles in multiple physiological processes. Here, we report a novel mechanism underlying cell polarity and uropod retraction.

The Effect of Spinal Cord Stimulation on Spinal Dorsal Horn Lipid Expression in Experimental Painful Diabetic Polyneuropathy: A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging Study.

Objectives: Diabetes-induced peripheral nerve fiber damage can cause painful diabetic polyneuropathy (PDPN), induced by central sensitization through proinflammatory processes in the spinal dorsal horn. Disturbances in spinal dorsal horn lipid metabolism play a major role in proinflammatory regulation. Conventional (Con)-spinal cord stimulation (SCS) is an alternative treatment for pain relief in PDPN, whereas differential target multiplexed (DTM)-SCS could be more effective than Con-SCS, specifically targeting the spinal inflammatory response.