Publications by authors named "G A C Franken"
Background: The distal convoluted tubule (DCT) plays an indispensable role in magnesium (Mg) reabsorption in the kidney. Yet, the extrusion mechanism of Mg has not been identified. The solute carrier 41A3 (SLC41A3) has been suggested to be involved in Mg extrusion, but this has never been conclusively demonstrated.
View Article and Find Full Text PDFAdaptive immunity relies on dendritic cell (DC) migration to transport antigens from tissues to lymph nodes. Galectins, a family of β-galactoside-binding proteins, control cell membrane organisation, exerting crucial roles in multiple physiological processes. Here, we report a novel mechanism underlying cell polarity and uropod retraction.
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- Long-term conventional spinal cord stimulation (LT-SCS) is effective for treating painful diabetic peripheral neuropathy (PDPN) initially, but its effectiveness may decline over time.
- *In a rat study, LT-SCS led to increased thresholds for mechanical hypersensitivity and changes in nerve fiber density, indicating structural adaptations in response to pain.
- *The study suggests that LT-SCS reduces certain proteins associated with pain pathways, revealing potential mechanisms for its effectiveness in managing PDPN symptoms.*
Objectives: Diabetes-induced peripheral nerve fiber damage can cause painful diabetic polyneuropathy (PDPN), induced by central sensitization through proinflammatory processes in the spinal dorsal horn. Disturbances in spinal dorsal horn lipid metabolism play a major role in proinflammatory regulation. Conventional (Con)-spinal cord stimulation (SCS) is an alternative treatment for pain relief in PDPN, whereas differential target multiplexed (DTM)-SCS could be more effective than Con-SCS, specifically targeting the spinal inflammatory response.
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