Background: The distal convoluted tubule (DCT) plays an indispensable role in magnesium (Mg) reabsorption in the kidney. Yet, the extrusion mechanism of Mg has not been identified. The solute carrier 41A3 (SLC41A3) has been suggested to be involved in Mg extrusion, but this has never been conclusively demonstrated.
View Article and Find Full Text PDFAdaptive immunity relies on dendritic cell (DC) migration to transport antigens from tissues to lymph nodes. Galectins, a family of β-galactoside-binding proteins, control cell membrane organisation, exerting crucial roles in multiple physiological processes. Here, we report a novel mechanism underlying cell polarity and uropod retraction.
View Article and Find Full Text PDFObjectives: Diabetes-induced peripheral nerve fiber damage can cause painful diabetic polyneuropathy (PDPN), induced by central sensitization through proinflammatory processes in the spinal dorsal horn. Disturbances in spinal dorsal horn lipid metabolism play a major role in proinflammatory regulation. Conventional (Con)-spinal cord stimulation (SCS) is an alternative treatment for pain relief in PDPN, whereas differential target multiplexed (DTM)-SCS could be more effective than Con-SCS, specifically targeting the spinal inflammatory response.
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