Stratified Medicine Paediatrics: Cell free DNA and serial tumour sequencing identifies subtype specific cancer evolution and epigenetic states.

We profiled a large heterogenous cohort of matched diagnostic-relapse tumour tissue and paired plasma-derived cell free DNA (cfDNA) from patients with relapsed and progressive solid tumours of childhood. Tissue and cfDNA sequencing results were concordant, with a wider spectrum of mutant alleles and higher degree of intra-tumour heterogeneity captured by the latter, if sufficient circulating tumour-derived DNA (ctDNA) was present. Serial tumour sequencing identified putative drivers of relapse, with alterations in epigenetic drivers being a common feature.

Data collation for climate-cooling gas dimethylsulfide in Antarctic snow, sea ice and underlying seawater.

Dimethylsulfide (DMS) is a climatically active volatile sulfur compound found in Earth's oceans and atmosphere that plays an important role in cloud formation. DMS originates from its precursor dimethylsulfoniopropionate (DMSP), which is produced by several classes of phytoplankton. Concentrations of DMS and DMSP in Antarctic sea ice, snow and underlying seawater are not well documented and there is currently no dataset available to find the existing data.

C2H2-zinc-finger transcription factors bind RNA and function in diverse post-transcriptional regulatory processes.

Cys2-His2 zinc-finger proteins (C2H2-ZNFs) constitute the largest class of DNA-binding transcription factors (TFs) yet remain largely uncharacterized. Although certain family members, e.g.